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Pharmacology: Pharmacodynamics: Normal cellular activities depend on the availability of the biochemical energy derived mainly from the food nutrients. In the metabolic systems of 1he body, the substrates or breakdown products of carbohydrates, fats and proteins must be acted upon by enzymes together with their co-enzymes (primarily vitamins B1, B6 and B12).
B vitamins are necessary in order that the processes by which these substrates are further transformed may continue. Vitamin B1 + B6 + B12 stimulate the various metabolic processes which produce the energy needed to fuel the cellular activities of the body, specifically the physiologic activities of the nervous system. As the well known actions of B1, B6 and B12 are directed towards the CNS, the purported actions of high doses of these major vitamins in Vitamin B1 + B6 + B12 (MEGANERV 300 Capsule) revolve around the central nervous system. Vitamin B1 + B6 + B12 (MEGANERV 300 Capsule) has sufficient concentration of B1, thiamine mononitrate. Thiamine Mononitrate as a co-enzyme of carbohydrate metabolism, ensures the efficient production of energy from glucose into other metabolites such as ribose, a major component of DNA and RNA. Glucose provides the basic nutritional needs of the nervous system. The cells of the nervous system depend entirely on glucose as its energy source. Independent of its co-enzyme function, thiamine acts as a modulator in neuromuscular transmission. Vitamin B1 + B6 + B12 (MEGANERV 300 Capsule), with its high concentration of pyridoxine hydrochloride, is involved in several metabolic transformations of amino acids for tissue building and repair and in the biosynthesis of certain compounds such as neurotransmitters and blood elements needed for hematopoiesis.
Vitamin B1 + B6 + B12 (MEGANERV 300 Capsule) contains substantial amount of cyanocobalamin, a co-enzyme which promotes metabolism of nucleic acids, fats and proteins. Therefore, it is necessary in the formation of new cells and in the repair of nerve tissues.
The high amounts of B1, B6 and B12 in MEGANERV 300 Capsule will help optimize nutrition of the neurons thereby promoting efficient functioning of the nervous system.
Pharmacokinetics: Following oral administration, thiamine is absorbed from the gastrointestinal tract and is widely distributed to most body tissues. Thiamine is mostly present within the cells as diphosphate.
Thiamine is not stored in the body and amounts in excess of the body's requirements are excreted in the urine as unchanged thiamine or as metabolites.
Pyridoxine is readily absorbed from the gastrointestinal tract. It is converted to the active form pyridoxal phosphate and is stored mainly in the liver. Amounts in excess of the body's requirements are excreted unchanged in the urine. Pyridoxal diffuses across the placenta and appears in breast milk.
Vitamin B12 compounds which bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa are then actively absorbed from the gastrointestinal tract. Little amount is absorbed by passive diffusion but the process becomes increasingly important with larger or therapeutic amounts.
Vitamin B12 is extensively bound to transcobalamin, a plasma protein. Vitamin B12 is stored in the liver and is excreted in the bile. Part of a dose is excreted in the urine. Vitamin B12 diffuses across the placenta and is also distributed into breast milk.
